GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs875971 | 1 | rs4718344 | chr7:65874381 | GUSB | chr7:65425675-65447246:- | 0.28 | 5.47 | 7.42E-8 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs4718344 | chr7:65874381 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.31 | 6.19E-39 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs4718357 | chr7:65960878 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.23 | 2.81E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs4718357 | chr7:65960878 | GUSB | chr7:65425675-65447246:- | 0.27 | 5.3 | 1.8E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs4718357 | chr7:65960878 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.11 | 4.76E-38 | Aortic root size |
| THCA | cis | rs10262624 | 1 | rs4722286 | chr7:23913624 | C7orf46 | chr7:23719749-23742268:+ | -0.12 | -3.74 | 0.000209 | Schizophrenia |
| THCA | cis | rs4723738 | 1 | rs4723733 | chr7:38223613 | STARD3NL | chr7:38217933-38270269:+ | 0.52 | 12.37 | 1.13E-30 | Treatment response for severe sepsis |
| THCA | cis | rs4723738 | 1 | rs4723734 | chr7:38232061 | STARD3NL | chr7:38217933-38270269:+ | -0.52 | -12.38 | 9.54E-31 | Treatment response for severe sepsis |
| THCA | cis | rs4723738 | 1 | rs4723738 | chr7:38240908 | STARD3NL | chr7:38217933-38270269:+ | -0.52 | -12.16 | 8.05E-30 | Treatment response for severe sepsis |
| THCA | cis | rs472402 | 1 | rs472402 | chr5:6635591 | NSUN2 | chr5:6599355-6633157:- | 0.19 | 4.15 | 3.88E-5 | Response to amphetamines |
| THCA | cis | rs683250 | 1 | rs472415 | chr11:83267166 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.94 | 9.5E-5 | Subcortical brain region volumes |
| THCA | cis | rs11976180 | 1 | rs4726669 | chr7:143758191 | ARHGEF35 | chr7:143883677-143892736:- | -0.5 | -10.62 | 8.54E-24 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs4726669 | chr7:143758191 | OR2A1 | chr7:144015236-144016148:+;chr7 | -0.19 | -4.01 | 7.07E-5 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs4726669 | chr7:143758191 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.3 | -6.58 | 1.23E-10 | Obesity-related traits |
| THCA | cis | rs4727443 | 1 | rs4727443 | chr7:99593346 | TRIM4 | chr7:99488037-99517154:- | -0.3 | -5.81 | 1.13E-8 | Interstitial lung disease |